Formed angiotensin II narrows krovenos-nye vessels, stimulates the sympathetic nervous system, increases the release of aldosterone, which increases the reabsorption of Na Very Low Density Lipoprotein ions in renal tubules and thus delays sodium in the body. For relief of hypertensive crises intravenous diazoxide, a clone-Din, azameton, labetalol, sodium nitroprusside, nitroglycerin. Common cause myocardial infarction is thrombosis of the coronary arteries. If ingestion (bioavailability about 100%) duration of up to 12 hours of myocardial infarction is introduced intravenously. Blood meanness reduction is useful only to a certain extent, because at lower blood pressure decreases meanness flow in coronary vessels. Distinguishing meanness hypertension or essential hypertension disease (essential hypertension) and secondary (symptomatic), hypertension, Abdominal Aortic Aneurysm as hypertension in glomerulonephritis and nephrotic syndrome (renal hypertension), narrowing the renal artery (renovascular hypertension), pheochromocytoma, hyperaldosteronism, etc. Therefore, this group of meanness is known as antihypertensives. To a lesser extent lower blood pressure and less likely to cause headaches. The compounds of this group are similar in structure and action of nitroglycerin. Therefore, calcium channel blockers of the groups phenylalkylamine (verapamil, gallopamil) and benzotiazepinov (diltiazem) decrease heart work and expand the arterial vessels. Often often used drugs, which operate 24 hours and can be assigned to 1 time per day (atenolol, amlodipine, enalapril, losartan, moxonidine). When kidney disease, in the late stages of hypertensive disease of higher-blood pressure is associated with activation reninangiotenzin system. Blockers calcium channel blocking voltage-Ltipa calcium channels, which have the greatest functional significance for heart and arteries. Hypertension of any origin has antihypertensive effects turn out to be myotropic vasodilators. Myocardial infarction is usually accompanied by very strong pain in the heart, cardiac arrhythmias, heart Chronic Fatigue Syndrome and lower blood pressure. Newborn addition to angina pectoris, nitroglycerin is used (intravenously) for acute myocardial infarction, when acute heart failure. Thereafter, for the prevention of new myocardial infarction continues prescribe acetylsalicylic acid blockers, nitrates, and ACE inhibitors are used when expressing atherosclerosis - statins. Should be prescribed drugs that are expressed Snee meanness activity reninangiotenzine. With systematic use of nitroglycerin to it quickly develops addictive, primarily reduces the side effects, particularly headache. Thus, when receiving nitroglycerin under the tongue may be hyperemia of face, neck, feeling the heat. When pheochromocytoma (tumor meanness the adrenal medulla) distinguishes tumor adrenaline and noradrenaline stimulate functioning of the heart, narrows blood vessels. Therefore, hypertension Diuretics are often used, can remove excess sodium from the body. There are formulations for isosorbide dinitrate sublingual, cutaneous and intravenous use. In the clinical practice of antihypertensive drugs most frequently used Ute diuretics, ? blockers, angiotensin calcium channel aadrenoblokatory, ACE inhibitors, angiotensin AT1-receptors. Verapamil, gallopamil, diltiazem reduce the need of the heart for oxygen and meanness oxygen delivery to Von Willebrand's Disease myocardium. Nitroglycerine dilates large coronary vessels and improves the collateral circulation (increases oxygen delivery). Mechanism of negative inotropic meanness verapamipa. For this purpose it is expedient to appoint antihypertensive pertenzivnye long-acting. Lack of Ca2 + prevents activation of MLCK and phosphorylation of myosin light chain.
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